منابع مشابه
Ethnobotany, Ethnopharmacology and Drug Discovery
This manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. It includes either a brief definition of both fields and presenting some examples on them. Also it has a glimpse on the geographical coverage of research works throughout the world, important issue of prope...
متن کاملIs combinatorial chemistry on the right track for drug discovery?
Critical to the effective implementation of high throughput methods of synthesis is the necessity for a significant supporting level of automation. There are a number of critical issues associated with the successful introduction, and supporting role, of automation of small molecule chemical synthesis. Clearly there are needs for automation to increase drug candidate synthesis throughput. Autom...
متن کاملRecent advances in combinatorial biosynthesis for drug discovery
Because of extraordinary structural diversity and broad biological activities, natural products have played a significant role in drug discovery. These therapeutically important secondary metabolites are assembled and modified by dedicated biosynthetic pathways in their host living organisms. Traditionally, chemists have attempted to synthesize natural product analogs that are important sources...
متن کاملCDA: Combinatorial Drug Discovery Using Transcriptional Response Modules
BACKGROUND Anticancer therapies that target single signal transduction pathways often fail to prevent proliferation of cancer cells because of overlapping functions and cross-talk between different signaling pathways. Recent research has identified that balanced multi-component therapies might be more efficacious than highly specific single component therapies in certain cases. Ideally, synergi...
متن کاملApplication of combinatorial chemistry science on modern drug discovery.
Drug discovery is a competitive discipline that requires constant innovation and refinement as a combination of market, patient, and regulatory concerns require that company’s balance their novel, clinically unvalidated molecular targets with validated targets (KO, ASO, siRNA) because the attrition rate for novel targets is substantial. The dramatic consolidations across the pharmaceutical indu...
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ژورنال
عنوان ژورنال: Journal of Pesticide Science
سال: 2003
ISSN: 1348-589X,1349-0923
DOI: 10.1584/jpestics.28.86